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Human RegulomeDB: Unlocking the Secrets of Non-Coding DNA


The Human RegulomeDB project provides a critical resource for researchers investigating gene regulation and its impact on human health. With the understanding that most genetic variations linked to diseases reside in non-coding regions of the genome, RegulomeDB offers a comprehensive platform for analyzing and interpreting these variations.

Established in 2012, RegulomeDB stands out for its ability to:

  • Integrate and curate vast amounts of existing data on regulatory elements within non-coding regions.
  • Annotate and display the functional and biochemical aspects of these regulatory elements at nucleotide resolution.
  • Collect and analyze data from individual labs and consortia, including information on gene expression, transcription factor binding, chromatin modification, and DNA methylation.
  • Connect regulatory data to sequence variations identified through large-scale projects like dbSNP, the 1000 Genomes Project, and GWAS studies.

The user-friendly web interface of RegulomeDB allows researchers to easily access this valuable information and gain deeper insights into the complex regulatory mechanisms governing gene expression and human disease.


  • US National Institutes of Health, National Human Genome Research Institute (grant U41 HG009293)

Explore Human RegulomeDB and unlock the secrets of non-coding DNA!