RegulomeDB
Main content start
Human RegulomeDB: Unlocking the Secrets of Non-Coding DNA
The Human RegulomeDB project provides a critical resource for researchers investigating gene regulation and its impact on human health. With the understanding that most genetic variations linked to diseases reside in non-coding regions of the genome, RegulomeDB offers a comprehensive platform for analyzing and interpreting these variations.
Established in 2012, RegulomeDB stands out for its ability to:
- Integrate and curate vast amounts of existing data on regulatory elements within non-coding regions.
- Annotate and display the functional and biochemical aspects of these regulatory elements at nucleotide resolution.
- Collect and analyze data from individual labs and consortia, including information on gene expression, transcription factor binding, chromatin modification, and DNA methylation.
- Connect regulatory data to sequence variations identified through large-scale projects like dbSNP, the 1000 Genomes Project, and GWAS studies.
The user-friendly web interface of RegulomeDB allows researchers to easily access this valuable information and gain deeper insights into the complex regulatory mechanisms governing gene expression and human disease.
Funding:
- US National Institutes of Health, National Human Genome Research Institute (grant U41 HG009293)
Explore Human RegulomeDB and unlock the secrets of non-coding DNA!